What to Do if Antihistamines Stop Working for a Hives Rash

Hives are raised red welts or splotches that tend to be itchy, tender, and swollen. They can come up suddenly and form anywhere on your body.

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In many cases, over-the-counter antihistamines (also known as H1 antihistamines) tend to be enough to provide relief, says Nicole Weiler, MD, a dermatologist and clinical assistant professor of dermatology at NYU Langone Health in New York City. These medications block histamine, a chemical signal released in your body as a response to inflammation, which may be prompted by exposure to an allergen (like food or pollen) or to an infection (like a virus).

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